Study proposes a novel insulin-centered mechanism for ketogenic diet-associated hypercholesteremia and highlights a potential new approach to lipid management TOWARD...
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PEER-REVIEWED
Frontiers in Nutrition · 2025
Published 12-month outcomes from 50 employees enrolled in the TOWARD metabolic health intervention.
Buchanan L, Calkins M, Kalayjian T, Norwitz NG, Teicholz N, Unwin D, Soto-Mota A
Intention-to-treat analysis · 50 employees
Four primary outcomes from the peer-reviewed 12-month analysis.
Mean weight loss
15.5% of initial body weight · intention-to-treat analysis
Medications deprescribed
8 medications started
Estimated annual medication savings
Per participant · GoodRx estimates, January 2024
Completed one year
82% retention
Method and context
A real-world workplace partnership between a self-insured manufacturing company and a metabolic health clinic.
50 employees enrolled; mean baseline BMI was 43.2 ± 8.7 kg/m²
64% had prediabetes or type 2 diabetes
12-month follow-up with intention-to-treat analysis for weight outcomes
Connected intervention combining therapeutic carbohydrate reduction, coaching, remote monitoring, and community support
Study context Real-world pilot without a formal control group; employees voluntarily applied
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